Polycythamia Vera Treated with Phenylhydrazine
نویسندگان
چکیده
منابع مشابه
The Reduction of Hypercalcemia in Cases of Polycythemia Vera by Phenylhydrazine.
The range of variation in serum calcium is relatively narrow in health and in most diseases. The accepted normal level is from 9 to 11 mgm. for each 100 cc. of serum or plasma. Lowered values for serum calcium have been found in tetany (parathyroid), rickets, nephritis, osteomalacia and sprue; elevated values are rare. High values have been found by Wells in terminal acidosis and by Coates and ...
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The cancer potencies of phenylhydrazine and phenylhydrazine hydrochloride were estimated from dose-response data from three data sets: lung tumors among male and female mice (combined) exposed orally to phenylhydrazine hydrochloride (Clayson et al., 1966) and blood vessel tumors among male and female mice exposed orally to phenylhydrazine hydrochloride (Toth and Shimizu, 1976). Studies of pheny...
متن کاملCardiac hypertrophy in rats with phenylhydrazine anemia.
THIS investigation was undertaken for the purpose of studying the effect of anemia upon the hearts of rats, of determining whether cardiac hypertrophy occurs, and, if so, of studying the mechanism of hypertrophy. In spite of the widespread belief that cardiac hypertrophy does occur with anemia, Stembridge and Rigdon have indicated the lack of evidence to support many of the reported cases. Thei...
متن کاملPhenylhydrazine haematotoxicity
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-ind...
متن کاملThe Reaction of Phenylhydrazine with Microsomal Cytochrome
Phenylhydrazine interacted with oxidized and reduced cytochrome P-450 of rat liver microsomes to produce binding difference spectra typical of many nitrogenous compounds. The phenylhydrazine-induced difference spectrum observed with oxidized microsomal cytochrome P-450 was converted, in a time-dependent process, t o yield a new spectral intermediate with an absorbance maximum around 480 nm. ...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1930
ISSN: 0035-9157
DOI: 10.1177/003591573002300414